What Are Polynucleotides and Why Are Aesthetics Professionals Using Them?

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Polynucleotide therapy

The constantly changing world of skincare and aesthetics also brings about scientifically based solutions that often change our concepts of beauty, health, and rejuvenation. Among these new treatments is polynucleotide therapy, a regenerative skin therapy that is indeed taking the skincare industry by storm in a very disruptive way. 

We at Dr. Ram Aesthetics are very pleased to be among the first clinics in the world to present such an exceptional treatment that not only revitalizes the skin but also utilizes the body’s mechanisms to bring back the pleasant and natural glow of the skin from within.  But, what are polynucleotides, and why are more aesthetics practitioners recommending them now more than ever?”

What Are Polynucleotides? 

polynucleotide therapy is made up of nucleotides, which indicates that they are the lengthy filaments of the tiniest constituents of DNA and RNA. Their main roles are to keep and hand over genetic data in the case of medicine, but in the case of skin care, they have already seemed to take up a much different and powerful role: renewal.

Skin treatment polynucleotides, for example, are obtained from sources that are purified, non-immunogenic, and biocompatible (let’s say salmon DNA), thus, completely safe, and tolerated by the body. Once in the dermis, the polynucleotide therapy acts as bio-stimulators, very close to turning your own cells on to regenerate, repair, and retain water.

In a nutshell, we  promote natural skin healing from the inside out, and indeed they do work!

How Do Polynucleotides Work in the Skin? 

Polynucleotides  are injected into the dermis using fine needles or mesotherapy. Once placed in the skin, the polynucleotides go to work on a cellular basis, activating a number of important mechanisms:

1. Stimulates Fibroblasts to create Collagen 

Fibroblasts are the skin cells that generate collagen and elastin, which are the structural proteins that make the skin plump and firm thereby giving a youthful appearance. The polynucleotide therapy  grants the fibroblasts the signal to produce new collagen by improving the elasticity of the skin.

2. Enhances skin hydration from the inside out 

Polynucleotide therapy also elicits many of the water molecules and greatly assists in skin hydration. They help calm dry, flaky skin and promote soft, dewy, and refreshed skin. Hydrated skin is more resilient, youthful, and fresh.

3. Enhances microcirculation 

When polynucleotides are introduced into the skin, they enhance blood flow at the micro level. Improved circulation equals increased oxygen and nutrients to your cells, resulting in improved cell function and support for regional repair of tissue.

4. Reduces Inflammation and Redness 

The healing properties of the treatment are outstanding and can be useful for inflammation-prone conditions like sensitive skin, rosacea, or post-acne redness. The combination of anti-inflammatories will not only soothe the irritation but also shorten the time for the skin to heal. Additionally, we act quickly, thus making them suitable for hypersensitive skin.

5. Repairing Damaged Skin Cells 

Every day environmental damage, UV damage, aging – all of the stressors mentioned hide the skin’s natural repair mechanisms. Fortunately, polynucleotides help “wake up” those sluggish skin cells and assist skin cells in getting back to their original repair functions, to support healthier, more vibrant skin.

Why Are Aesthetics Professionals Using Polynucleotides? 

This treatment is quickly becoming more common in clinics, and rightfully so. Aesthetics Professionals appreciate polynucleotides not only for their performance but also for their safety and flexibility.

1. They’re Biocompatible and Safe 

Because polynucleotides come from a natural source that is genetically similar to human DNA, the human body accepts them with ease. There is little possibility of allergic reactions or side effects, which ranks it as one of the safest injectable treatments available today.

2. It’s a Truly Regenerative Treatment 

Unlike fillers that simply add volume or serums that only hydrate the surface, polynucleotides rebuild the skin’s foundation. They regenerate skin from within, offering longer-lasting and more natural results.

3. Treats Multiple Concerns at Once 

Polynucleotides can combat multiple issues – fine lines, dullness, dry skin, acne scars, dark circles, and even pigmentation issues. This makes it a wonderful option for patients looking for a complete skin reset. 

4. Limited Downtime, Major Impact 

Most patients only experience some red or slightly swollen skin for 24–48 hours after treatment. Unlike lasers or aggressive peels, there’s no hiding out for days after treatment! You can easily get back to your regular routine without any fuss. 

5. Works Well With Other Treatments 

It is possible at the same time, polynucleotide injections api, procedures like microneedling, platelet rich plasma, or fillers, to be done together. The combined effect of these treatments gives you more of an aesthetic advantage and at the same time permits a more widespread skin rejuvenation method.

Who is the best candidate for Polynucleotide Treatments? 

This treatment has one of the most significant benefits in its wide appeal. It’s not just for mature skin – it’s beneficial for almost anyone looking to improve skin health.

Perfect for: 

  • People in their 20s or 30s want to prevent early signs of aging
  • Individuals in their 40s 60s dealing with volume loss, sagging, or wrinkles
  • Those with acne scarring or pigmentation
  • People with sensitive or inflamed skin
  • Anyone seeking a natural, long-term solution for better skin

We offer personalised treatments that are tailored to your skin’s present condition and your desired results.

What Happens During the Treatment? 

Here’s a step-by-step look at what to expect when you book your polynucleotide treatment.

Step 1: Consultation 

We will begin by determining your skin type, problem areas and cosmetic goals. We will explain the treatment and procedure, and take any questions you may have.

  • Step 2: Cleansing and Preparation 

Dr. Ram Aesthetics begin to thoroughly cleanse your skin. We then apply a topical numbing cream to ensure comfort.

  • Step 3: Injection Process 

We use very small needles or a mesotherapy action to inject small quantities of polynucleotide solution into the desired area.

  • Step 4: Post-Procedure Advice 

You may notice some redness or swelling that goes away quickly. We will give you simple aftercare advice, if needed, which is usually to keep you to your normal activities with very few changes.

  • Step 5: Follow-Up and Maintenance 

It is best for most patients to have 3–4 sessions a few weeks apart to achieve optimal results. We will develop a plan for maintenance to match your skin’s needs.

When Will You See Results? 

Most patients can see a change in the texture, hydration, and glow of their skin in 7-10 days. The process of real change will occur in subsequent months as your skin continues to regenerate itself and rebuild its collagen!

Timeline of Results: 

  • Week 1–2: Softer texture and better hydration
  • Week 3–4: Improved elasticity and reduction in fine lines
  • Week 5+: Clearer, brighter, and more youthful skin tone

With regular treatments, these results can last 6–12 months or longer.

Final Thoughts + Your Invitation

Polynucleotides are the future of regenerative skincare – they are natural, science based and absolutely correcting. If underneath the surface you want real change, this treatment might just be your perfect match.

Ready to boost your skin’s health from the inside out?
Book your consultation at Dr. Ram Aesthetics today and discover how polynucleotides can reveal your most youthful, glowing skin yet.

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